There is no single magic pill as some marketers are saying

We make a difference using latest research and data analytics

Scientific Evidence

Probiotics are effective treatments for IBS, although which individual species and strains are the most beneficial remains unclear. – in The American Journal of Gastroenterology 109, 1547-1561 (October 2014), review of 43 randomized controlled trials.

There is strong evidence for probiotics as a treatment for digestive issues such as the Irritable Bowel Syndrome. Recent reviews of many randomized controlled trials have shown that symptoms such as bloating, pain and stool inconsistencies can be improved significantly by taking probiotics.

However, there is no single magic bacterial strain that will solve your issues or a special “proprietary formula”.

In an industry overrun with false labels and magic pills we will give you all the information you need, as well as the science behind it.

The truth is that scientists know that there are bacterial strains showing effects, but it is unclear which combination of strains can help you as an individual person with your unique metabolism and microbiome. This problem can only be solved by getting insights into your unique gut flora and symptoms. Which is what we do.

We aren’t marketers and business guys, but a team of medical doctors, developers and data scientists

Learn how we personalize probiotics for you

Our Experts

It can take years until the latest research makes it into a new product. We are working closely with the leading doctors and scientists in digestive health. Our experts help us to enrich our algorithms with scientific evidence.

PD Dr.rer.nat. Beate Niesler

beate-niesler_small

Group Leader Genetics of Neurogastroenterologic Disorders & Head of nCounter Core Facility
University of Heidelberg, Institute of Human Genetics, Department of Human Molecular Genetics

Dr. med. Viola Andresen, Msc.

Science

Specialist in internal medicine at the Israelitic Hospital in Hamburg, head of the nutrition team, member of the Rome IV Committee of the Rome Foundation for Functional Gastrointestinal Disorders

Prof. Dr. med. Peter Layer

Science

Medical director at the Israelitic Hospital in Hamburg, member of the advisory board at German Society for Digestive and Metabolic Diseases, first author of the German Consensus Guidelines on IBS

Dr. Dipl.-Psych. Christina Rosenberger

Science

University Hospital Hamburg-Eppendorf, co-author of the German consensus guidelines on IBS

Our manufacturers

supply-chain

The quality of a premium product – tailored to you

For the manufacturing of our probiotics we are cooperating with manufacturers producing probiotics at the highest quality standards. From the patented capsules to scientifically researched bacterial strains – we can make sure that they match the highest quality possible. The composition of our bacterial strains is unique and not comparable to any probiotic product currently on the market, because it’s based on latest research and analysis of the data of 1000s of users using the Cara App.

Our bacterial strains

We’ve selected bacterial strains which have been scientifically shown to have highly positive effects from the world’s leading probiotic laboratories. There is scientific evidence in a variety of fields.

Stool Inconsistencies

Probiotics support healthy bowel movements. They can decrease the frequency of bowel movements which is beneficial for people with diarrhea.

8, 9, 10, 11, 23, 28, 29, 32, 33

Digestive Issues/IBS

A reduction in stomach ache, bloating and flatulence makes probiotics the perfect natural supplement.

7, 24, 25, 26

Allergies

Many people are suffering from hay fever, asthma or food allergies. According to 12 controlled trials it was possible to reduce allergy symptoms by using probiotics.

16, 17, 18

Improved Mental Health

There is a strong connection between our gut (nervous system) and our brain. Studies have shown that probiotic intake can reduce depression scores significantly in patients with both digestive and mental issues.

12, 13, 14, 21

Lactose Intolerance

Probiotics have shown an alleviation of symptoms, because some strains support lactose breakdown in the small intestine and an improved tolerance in the large intestine

1, 2, 3, 4, 5, 6

Immune health

Probiotics help to prevent colds. A review of 12 controlled trials showed that around half as many study participants became ill if they had taken probiotics and that probiotics made it possible to reduce the duration of illness by almost two days. Less antibiotics were prescribed for those who took probiotics.

18, 19, 20
Lactobacillus

Lactobacillus is a well known genus living in the human gut (and also at a number of other body sites). This bacterium is part of a group of bacteria that produce lactic acid. In fact, they convert sugars to lactic acid. Studies showed that Lactobacillus can help people with Lactose Intolerance. There is an increased breakdown of lactose in the small intestine by probiotics (probiotic cultures themselves release the lactase enzyme which breaks down lactose) and a positive effect on the microflora in the large intestine by which means the lactose is better tolerated and more easily absorbed.

Lactobacillus can inhibit the growth of the fungal pathogen candida albicans. Studies have shown that people with digestive issues often have a low level of lactobacilli and bifidobacteria.

Our strains:

  • Lactobacillus bulgaricus
  • Lactobacillus acidophilus
  • Lactobacillus casei
  • Lactobacillus paracasei
  • Lactobacillus plantarum
  • Lactobacillus rhamnosus
  • Lactobacillus salivarius
  • Lactobacillus gasseri

References: 1, 2, 3, 4, 5, 6, 15, 21, 24, 25, 26, 28, 29

Bifidobacterium

The genus Bifidobacterium is an ubiquitous inhabitant of the human gut. Bifidobacteria can produce lactic acid and have the ability to ferment carbohydrates. In clinical use, Bifidobacteria are often used to improve rates of remission in ulcerative colitis. Several benefits of the Bifidobacterium as a probiotic supplement have been found, such as reducing symptoms of the Irritable Bowel Syndrome, helping people with lactose intolerance and reduction of stool inconsistencies.

Our strains:

  • Bifidobacterium breve
  • Bifidobacterium lactis
  • Bifidobacterium longum
  • Bifidobacterium bifidum

References:  21, 22, 27

Streptococcus

Streptococcus is widely known as a dangerous genus, causing infections like pharyngitis and many others. However, the detail makes the difference because there is a complete harmless species called streptococcus thermophilus which has been used for years in the food industry to produce yoghurt and cheese. Usage in probiotics has shown beneficial effects for stool regulation, breakdown of lactose and symptom reduction in IBS patients.

Our strains:

  • Streptococcus thermophilus

References: 30, 31, 9, 22

Saccharomyces

Different to other probiotics saccharomyces is not a bacterium, but a yeast. Species like saccharomyces boulardii have been studies extensively and have been shown to be beneficial in different combination of symptoms. It helps to regulate stool frequencies in IBS patients and people with infectious diarrhea. There is also early research for treating people suffering from inflammatory bowel disease or limiting side effects of a helicobacter eradication. Don’t worry about fungal overgrowth. Except for cases with complete  immune suppression there is no reason to worry about side effects. Even HIV patients can benefit from saccharomyces to limit diarrhea as a symptom.

Our strains:

  • Saccharomyces boulardii
  • Saccharomyces cerevisiae

References: 23, 28, 32, 33, 34, 35

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Register of references (selection):
1) Vonk, R.J., Reckman, G.A., Harmsen, H.J. and Priebe, M.G., 2012. Probiotics and lactose intolerance. In Probiotics. InTech.

2) Pandey, K.R., Naik, S.R. and Vakil, B.V., 2015. Probiotics, prebiotics and synbiotics-a review. Journal of food science and technology, 52(12), pp.7577-7587. https://link.springer.com/article/10.1007%2Fs13197-015-1921-1

3) Kechagia, M., Basoulis, D., Konstantopoulou, S., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N. and Fakiri, E.M., 2013. Health benefits of probiotics: a review. ISRN nutrition, 2013.

4) Shi, L.H., Balakrishnan, K., Thiagarajah, K., Ismail, N.I.M. and Yin, O.S., 2016. Beneficial Properties of Probiotics. Tropical life sciences research, 27(2), p.73.

5) Staudacher, H., 2015. Probiotics for lactose intolerance and irritable bowel syndrome. British journal of community nursing, pp.S12-S14.

6) Linares, D.M., Ross, P. and Stanton, C., 2016. Beneficial microbes: the pharmacy in the gut. Bioengineered, 7(1), pp.11-20.

7) Ford, A.C., Quigley, E.M., Lacy, B.E., Lembo, A.J., Saito, Y.A., Schiller, L.R., Soffer, E.E., Spiegel, B.M. and Moayyedi, P., 2014. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. The American journal of gastroenterology, 109(10), p.1547.

8)Riddle, M.S. and Connor, B.A., 2016. The traveling microbiome. Current infectious disease reports, 18(9), p.29.

9)Zaidi, D. and Wine, E., 2015. An update on traveler´s diarrhea. Current opinion in gastroenterology, 31(1), pp.7-13.

10)Allen, S.J., Martinez, E.G., Gregorio, G.V. and Dans, L.F., 2010. Probiotics for treating acute infectious diarrhea. The Cochrane Library. https://www.ncbi.nlm.nih.gov/pubmed/21069673

11)McFarland, L.V., 2007. Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Medicine and Infectious Disease, 5(2), pp.97-105

12) Pinto-Sanchez, Maria Ines, et al. “Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: a Pilot Study in Patients With Irritable Bowel Syndrome.” Gastroenterology (2017).

13)Messaoudi, M., Violle, N., Bisson, J.F., Desor, D., Javelot, H. and Rougeot, C., 2011. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut microbes, 2(4), pp.256-261.

14)Pirbaglou, M., Katz, J., de Souza, R.J., Stearns, J.C., Motamed, M. and Ritvo, P., 2016. Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials. Nutrition Research, 36(9), pp.889-898. https://www.ncbi.nlm.nih.gov/pubmed/27632908

15) Wang, Z. K., Yang, Y. S., Stefka, A. T., Sun, G., & Peng, L. H. (2014). fungal microbiota and digestive diseases. Alimentary pharmacology & therapeutics, 39(8), 751-766.

16) Osborn, D.A. and Sinn, J.K., 2007. Probiotics in infants for prevention of allergic disease and food hypersensitivity. The Cochrane Library.

17) Vliagoftis, H., Kouranos, V.D., Betsi, G.I. and Falagas, M.E., 2008. Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. Annals of Allergy, Asthma & Immunology, 101(6), pp.570-579.

18) Kechagia, M., Basoulis, D., Konstantopoulou, S., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N. and Fakiri, E.M., 2013. Health benefits of probiotics: a review. ISRN nutrition, 2013.

19) Hao, Q., Dong, B.R. and Wu, T., 2015. Probiotics for preventing acute upper respiratory tract infections. The Cochrane Library.

20) Linares, D.M., Ross, P. and Stanton, C., 2016. Beneficial microbes: the pharmacy in the gut. Bioengineered, 7(1), pp.11-20.

21) Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589.

22) Ghouri, Y. A., Richards, D. M., Rahimi, E. F., Krill, J. T., Jelinek, K. A., & DuPont, A. W. (2014). Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease. Clinical and experimental gastroenterology, 7, 473.

23) de Chambrun, G. P., Neut, C., Chau, A., Cazaubiel, M., Pelerin, F., Justen, P., & Desreumaux, P. (2015). A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Digestive and Liver Disease, 47(2), 119-124.

24) Ford, A. C., Quigley, E. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., … & Moayyedi, P. (2014). Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. The American journal of gastroenterology, 109(10), 1547.

25) Ducrotté, P., Sawant, P., & Jayanthi, V. (2012). Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World journal of gastroenterology: WJG, 18(30), 4012.

26) Ducrotté, P., Sawant, P., & Jayanthi, V. (2012). Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World journal of gastroenterology: WJG, 18(30), 4012.

27) Eskesen, D., Jespersen, L., Michelsen, B., Whorwell, P. J., Müller-Lissner, S., & Morberg, C. M. (2015). Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. British Journal of Nutrition, 114(10), 1638-1646.

28) Guarino, A., Guandalini, S., & Vecchio, A. L. (2015). Probiotics for prevention and treatment of diarrhea. Journal of clinical gastroenterology, 49, S37-S45.

29) Ojetti, V., Ianiro, G., Tortora, A., D’Angelo, G., Di Rienzo, T. A., Bibbo, S., … & Gasbarrini, A. (2014). The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial. J Gastrointestin Liver Dis, 23(4), 387-391.

30) Sieuwerts, S., Molenaar, D., van Hijum, S. A., Beerthuyzen, M., Stevens, M. J., Janssen, P. W., … & van Hylckama Vlieg, J. E. (2010). Mixed-culture transcriptome analysis reveals the molecular basis of mixed-culture growth in Streptococcus thermophilus and Lactobacillus bulgaricus. Applied and environmental microbiology, 76(23), 7775-7784.

31) Beniwal, R. S., Arena, V. C., Thomas, L., Narla, S., Imperiale, T. F., Chaudhry, R. A., & Ahmad, U. A. (2003). A randomized trial of yogurt for prevention of antibiotic-associated diarrhea. Digestive diseases and sciences, 48(10), 2077-2082.

32) Kollaritsch, H., Kremsner, P. E. T. E. R., Wiedermann, G. E. R. H. A. R. D., & Scheiner, O. T. T. O. (1989). Prevention of traveller’s diarrhea: comparison of different non-antibiotic preparations. Travel Med Int, 6, 9-17.

33) Szajewska, H., Horvath, A., & Kołodziej, M. (2015). Systematic review with meta‐analysis: Saccharomyces boulardii supplementation and eradication of Helicobacter pylori infection. Alimentary pharmacology & therapeutics, 41(12), 1237-1245.

34) Guslandi, M., Mezzi, G., Sorghi, M., & Testoni, P. A. (2000). Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Digestive diseases and sciences, 45(7), 1462-1464.

35) Saint-Marc, T., Blehaut, H., Musial, C., & Touraine, J. L. (1995). AIDS-related diarrhea: a double-blind trial of Saccharomyces boulardii. Semaine des Hopitaux de Paris, 71(23), 735-741.